Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.10 extracted from

  • Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
    The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL (2009), Blood, 113, 2776-2790.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.10

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O Homo sapiens catalyzation of the final two steps of de novo purine biosynthesis pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P31939
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phophorylation increases enzyme activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
anaplastic large cell lymphoma cell ALCL cell line TS, Sup-M2 cells, JB-6 cells, SU-DHL1 cells Homo sapiens
-
CCRF-CEM cell
-
 Homo sapiens
-
HEK-293T cell immunoprecipitated from Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
KARPAS-299 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 proteomic approach to identify phophorylated proteins with a pathogenic role in transformation mediated by anaplastic lymphoma kinase (ALK), profiling of tyrosine-phosphorylation, mass spectrometry, anti-phosphotyrosine protein immunoprecipitation, posttranslational modification of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) formyltransferase/inosine monophosphate (IMP) cyclohydrolase (AICAR-FT/IMP-CHase, ATIC) by phosphorylation, enzyme is a direct target of anaplastic lymphoma kinase (ALK), phoshorylation increases enzyme activity posttranslational modification of a key purine synthesis enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + H2O catalyzation of the final two steps of de novo purine biosynthesis pathway Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AICAR-FT/IMP-CHase
-
 Homo sapiens
ATIC
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens