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BRENDA support

Literature summary for 3.5.4.10 extracted from

  • Szabados, E.; Manthey, M.K.; Wilson, P.K.; Christopherson, R.I.
    Inosine-5'-monophosphate analogues as inhibitors of human IMPcyclohydrolase and cellular growth (1998), Biochem. Mol. Biol. Int., 44, 617-623.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-chloroinosine 5'-monophosphate potent inhibitor Homo sapiens
2-flouroinosine 5'-monophosphate IC50-value in cell culture 0.0049 mM; potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide Homo sapiens de novo purine synthesis step 10 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CEM cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide de novo purine synthesis step 10 Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0049
-
IC50-value in cell culture 0.0049 mM Homo sapiens 2-flouroinosine 5'-monophosphate