Literature summary for 3.5.4.1 extracted from

Suspene, R.; Aynaud, M.M.; Guetard, D.; Henry, M.; Eckhoff, G.; Marchio, A.; Pineau, P.; Dejean, A.; Vartanian, J.P.; Wain-Hobson, S.
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism (2011), Proc. Natl. Acad. Sci. USA, 108, 4858-4863.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	a small fraction of human mitochondrial genomes are edited by APOBEC3 deaminases in the cytoplasm	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	a small fraction of human mitochondrial genomes are edited by APOBEC3 deaminases in the cytoplasm. Nuclear DNA tably segments of MYC and TP53, can be hyperedited by APOBEC3A	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	a small fraction of human mitochondrial genomes are edited by APOBEC3 deaminases in the cytoplasm. Nuclear DNA tably segments of MYC and TP53, can be hyperedited by APOBEC3A	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
APOBEC3	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	human mitochondrial and nuclear DNA are edited by APOBEC3A. The degree of editing is much greater in patients lacking the uracil DNA-glycolyase gene	Homo sapiens

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Release 2023.1 (January 2023)