Literature summary for 3.5.4.1 extracted from

Negroni, L.; Samson, M.; Guigonis, J.M.; Rossi, B.; Pierrefite-Carle, V.; Baudoin, C.
Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation (2007), Mol. Cancer Ther., 6, 2747-2756.

Search for more literature for 3.5.4.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach leads to intratumor chemotherapy using 5-fluorocytosine, which is locally converted to 5-fluorouracil, the treatment results in destruction of the gene-modified tumor, other physiological processes might contribute to the tumor destruction, overview	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine + H2O	Escherichia coli	treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview	uracil + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorocytosine + H2O	-	Escherichia coli	5-fluorouracil + NH3	-	?
cytosine + H2O	-	Escherichia coli	uracil + NH3	-	?
cytosine + H2O	treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview	Escherichia coli	uracil + NH3	-	?

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Release 2023.1 (January 2023)