Literature summary for 3.5.4.1 extracted from

Huber, B.E.; Austin, E.A.; Richards, C.A.; Davis, S.T.; Good, S.S.
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase (1994), Proc. Natl. Acad. Sci. USA, 91, 8302-8306.

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Application

Application	Comment	Organism
medicine	new approach to chemotherapy of cancer, using substrate 5-fluorocytosine orally and enzyme capsules implanted locally, using conversion of product 5-fluorouracil, a potent antineoplastic substance, which is strongly toxic for mammalian cells as chemotherapeutic tool against tumors, enzyme/prodrug gene therapy, artificial gene composed for metastatic colorectal carcinoma	Escherichia coli

Cloned(Commentary)

Cloned (Comment)	Organism
CD gene codA cloned into mammalian expression vector, WiDr cells, a human CRC cell line transformed	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine + H2O	Escherichia coli	-	uracil + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cytosine + H2O	-	Escherichia coli	uracil + NH3	-	?

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Release 2023.1 (January 2023)