Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-canavanine | a time-controlled, competitive, mechanism-based inhibitor, the close structural similarity between L-arginine and L-canavanine suggests that an analogous pathway is responsible for the inactivation-reactivation cycle; slow substrate inhibitor that functions by covalent modification of the active-site Cys406 residue in the form of a thiouranoim salt | Pseudomonas aeruginosa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | Pseudomonas aeruginosa | - |
L-citrulline + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Arg + H2O | - |
Pseudomonas aeruginosa | citrulline + NH3 | - |
? | |
L-arginine + H2O | - |
Pseudomonas aeruginosa | L-citrulline + NH3 | - |
? | |
L-arginine + H2O | via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview | Pseudomonas aeruginosa | L-citrulline + NH3 | - |
? | |
L-canavanine + H2O | via enzyme Cys-bound S-alkyl-thiouronium intermediate, residues Asp166 and Asp280 are involved, overview | Pseudomonas aeruginosa | O-ureidohomoserine + NH3 | product identification by mass spectrometry | ? |
Synonyms | Comment | Organism |
---|---|---|
ADI | - |
Pseudomonas aeruginosa |
More | the enzyme belongs to the L-arginine metabolizing, guanidino-transferring enzyme superfamily | Pseudomonas aeruginosa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Pseudomonas aeruginosa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.6 | - |
assay at | Pseudomonas aeruginosa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.7 | - |
L-canavanine | - |
Pseudomonas aeruginosa |