Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | DDAH1 forms a protein complex with Ras | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DDAH1 forms a protein complex with Ras | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDAH1 | - |
Mus musculus |
DDAH1 | - |
Homo sapiens |
dimethylarginine dimethylaminohydrolase | - |
Mus musculus |
dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DDAH1 knockout impairs endothelial sprouting from cultured aortic rings, and overexpression of constitutively active Akt or DDAH1 rescues endothelial sprouting in the aortic rings from these mice | Mus musculus |
malfunction | using selective gene silencing of DDAH1 with small interfering RNA and overexpression of DDAH1 in HUVEC, it is shown that DDAH1 acts to promote endothelial cell proliferation, migration and tube formation both by Akt phosphorylation as well as through the traditional role of degrading ADMA. DDAH1 overexpression increases Ras activity | Homo sapiens |