Literature summary for 3.5.3.18 extracted from

Lee, W.J.; Kim, S.H.; Kim, G.H.; Han, S.M.; Won, J.C.; Jung, C.H.; Park, H.S.; Choi, d.o..S.; Lee, K.U.; Park, J.Y.
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells (2010), Biochem. Biophys. Res. Commun., 398, 653-658.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bEnd3 cell	-	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	alpha-lipoic acid increases the gene expression and activity of DDAH, and signal transducer and activator of transcription STAT3 phosphorylation. Transfection of STAT3 increases DDAH II promoter activity, and alpha-lipoic acid amplifies it. alpha-Lipoic acid-induced increase in DDAH II promoter activity is attenuated in the promoter that has a mutation in the putative STAT3-binding site	up

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Release 2023.1 (January 2023)