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Literature summary for 3.5.3.18 extracted from

  • Gray, G.A.; Patrizio, M.; Sherry, L.; Miller, A.A.; Malaki, M.; Wallace, A.F.; Leiper, J.M.; Vallance, P.
    Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction (2010), Acta Histochem., 112, 413-423.
    View publication on PubMed
Search for more literature for 3.5.3.18

Application

Application Comment Organism
medicine seven days after coronary artery ligation, L-Arg and methylated arginine content, as well as DDAH activity are determined in homogenates of left ventricular infarct and border. In healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS. Following myocardial infarction, left ventricular DDAH activity is increased to 210% of control. Both DDAHI and DDAHII proteins are detected in peri-infarct cardiomyocytes, while DDAHII immunoreactivity is additionally localized to infiltrating inflammatory cells and blood vessels in the healing infarct. Both plasma and left ventricular concentrations of the DDAH substrate, ADMA, are increased post-myocardial infarction, although the ratio of Arg:ADMA is retained in the left ventricular post-myocardial infarction relative to sham operated controls Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
blood vessel DDAHII immunoreactivity is localized to infiltrating inflammatory cells and blood vessels in the healing infarct Rattus norvegicus
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cardiomyocyte both DDAHI and DDAHII proteins are detected in peri-infarct cardiomyocytes, while DDAHII immunoreactivity is additionally localized to infiltrating inflammatory cells and blood vessels in the healing infarct. Both plasma and left ventricular concentrations of the DDAH substrate, ADMA, are increased post-myocardial infarction Rattus norvegicus
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endocardium in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS Rattus norvegicus
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endothelium in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS Rattus norvegicus
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heart in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS Rattus norvegicus
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inflammatory cell DDAHII immunoreactivity is localized to infiltrating inflammatory cells and blood vessels in the healing infarct Rattus norvegicus
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Expression

Organism Comment Expression
Rattus norvegicus following myocardial infarction, left ventricular DDAH activity is increased to 210% of control up