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Literature summary for 3.5.3.18 extracted from

  • Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L.
    Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase (2005), J. Med. Chem., 48, 4670-4678.
    View publication on PubMed
Search for more literature for 3.5.3.18

Application

Application Comment Organism
medicine in vivo administration of DDAH inhibitors (2-amino-4-(NG-methyl-guanidino)butanoic acid and its analogues) increases plasma NG,NG-dimethyl-L-arginine levels, giving proof of concept that these can be used to probe the physiological effects of DDAH inhibition, with potential for pharmaceutical use of DDAH inhibitors in diseases where excess NO production is implicated Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-amino-4-(NG-methyl-guanidino)butanoic acid a series of analogues designed, reversible DDAH inhibitors Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NG,NG-dimethyl-L-arginine + H2O Rattus norvegicus
-
 L-citrulline + dimethylamine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NG,NG-dimethyl-L-arginine + H2O
-
 Rattus norvegicus L-citrulline + dimethylamine
-
 ?

Synonyms

Synonyms Comment Organism
DDAH
-
 Rattus norvegicus
dimethylarginine dimethylaminohydrolase
-
 Rattus norvegicus