Literature summary for 3.5.3.18 extracted from

Jiang, J.L.; Zhang, X.H.; Li, N.S.; Rang, W.Q; Feng-Ye, W.Q.; Hu, C.P.; Li, Y.J.; Deng, H.W.
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity (2006), Cardiovasc. Drugs Ther., 20, 281-294.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	probucol and the intracellular antioxidant pyrrolidine dithiocarbamate significantly attenuate inhibition of endothelial DDAH activity by oxidized-low density lipoprotein or lysophosphatidylcholine, but probucol or PDTC itself had no effect on the activity of DDAH	Homo sapiens

Application

Application	Comment	Organism
medicine	protective effect of probucol on endothelium related to enhancement of DDAH activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
lysophosphatidylcholine	-	Homo sapiens
lysophosphatidylcholine	activity is significantly decreased in cells treated with lysophosphatidylcholine (0.005 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamate significantly attenuate inhibition of DDAH activity by lysophosphatidylcholine	Rattus norvegicus
additional information	probucol or pyrrolidindithiocarbamate itself have no effect on the activity of DDAH	Rattus norvegicus
oxidized-low density lipoprotein	-	Homo sapiens
oxidized-low density lipoprotein	activity is significantly decreased in cells treated with oxidized-low density lipoprotein (0.1 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamat significantly attenuate inhibition of DDAH activity by oxidized-low density lipoprotein	Rattus norvegicus
sulfurosalicylic acid	inactivates DDAH	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	-	Rattus norvegicus	-
umbilical vein endothelial cell line	HUVEC-12 cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NG,NG-dimethyl-L-arginine + H2O	-	Rattus norvegicus	dimethylamine + L-citrulline	-	?

Synonyms

Synonyms	Comment	Organism
DDAH	-	Homo sapiens
DDAH	-	Rattus norvegicus
dimethylarginine dimethylaminohydrolase	-	Homo sapiens
dimethylarginine dimethylaminohydrolase	-	Rattus norvegicus

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Release 2023.1 (January 2023)