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Literature summary for 3.5.3.18 extracted from

  • Leiper, J.M.; Santa Maria, J.; Chubb, A.; MacAllister, R.J.; Charles, I.G.
    Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases (1999), Biochem. J., 343, 209-214.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.18

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.51
-
 NG-monomethyl-L-arginine DDAH I Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95865 2 dimethylarginine dimethylaminohydrolases: DDAH I and II
-

Source Tissue

Source Tissue Comment Organism Textmining
brain DDAH I is highly expressed Homo sapiens
-
heart DDAH II is highly expressed Homo sapiens
-
kidney DDAH I and DDAH II are highly expressed Homo sapiens
-
liver DDAH I is highly expressed, low level expression of DDAH II Homo sapiens
-
lung low level expression of DDAH II Homo sapiens
-
additional information DDAH I predominates in tissues that express neuronal nitric oxide synthase, DDAH II predominates in tissues expressing endothelial nitric oxide synthase Homo sapiens
-
pancreas DDAH I is highly expressed, low level expression of DDAH II Homo sapiens
-
placenta DDAH II is highly expressed Homo sapiens
-
skeletal muscle DDAH I and II is expressed at a low level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no hydrolysis of NG,NĀ‘G-dimethyl-L-arginine Homo sapiens ?
-
 ?
NG,NG-dimethyl-L-arginine + H2O
-
 Homo sapiens dimethylamine + L-citrulline
-
 ?
NG-monomethyl-L-arginine + H2O
-
 Homo sapiens citrulline + methylamine
-
 ?