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Literature summary for 3.5.3.15 extracted from
- Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development (2018), Sci. Rep., 8, 13263 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q08642 | isoform PAD2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Sertoli cell | - |
Mus musculus | - |
| TM-3 cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptidyl arginine deiminase | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | SOX9 positively regulates Padi2 transcription and FOXL2 antagonizes it in TM3 cells | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in fetal testes from Sox9 knockout mice, Pai2 expression is greatly reduced. Padi-/- XY mice are fertile and show no apparent reproductive anomalies. No significant difference in H3 citrullination between wildtype and Padi2-/- XY gonads is observed | Mus musculus |
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Release 2023.1 (January 2023)
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