Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-[(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl]benzamide | preferentially inhibits protein-arginine deiminase 2 by 3fold with the highest selectivity being observed for PAD2 over PAD4. Highly selective protein-arginine deiminase 2 inhibitor relative to the other protein-arginine deiminases | Homo sapiens | |
N-[(1S)-1-(2-tert-butyl-2H-tetrazol-5-yl)-4-[(2-fluoroethanimidoyl)amino]butyl][1,1'-biphenyl]-4-carboxamide | preferentially inhibits protein-arginine deiminase 2 by 25fold with the highest selectivity being observed for PAD2 over PAD4. Highly selective protein-arginine deiminase 2 inhibitor relative to the other protein-arginine deiminases | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UM07 | - |
- |
Homo sapiens | Q9Y2J8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | PAD2 is expressed in most tissues and cell types | Homo sapiens | - |
neutrophil | PAD4 is primarily expressed in neutrophils | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PAD2 | - |
Homo sapiens |
PAD4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme mediates histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular traps | Homo sapiens |