Literature summary for 3.5.3.15 extracted from

Damgaard, D.; Bjorn, M.E.; Jensen, P.O.; Nielsen, C.H.
Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase (2017), J. Enzyme Inhib. Med. Chem., 32, 1203-1208 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
H2O2	in vitro inhibitory to isoform Pad2 above 0.04 mM, peptidylarginine deiminase released from stimulated leukocytes is unaffected by exogenously added H2O2 at concentrations up to 1000 microM; in vitro inhibitory to isoform Pad4 above 0.04 mM, peptidylarginine deiminase released from stimulated leukocytes is unaffected by exogenously added H2O2 at concentrations up to 1000 microM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UM07	-	-
Homo sapiens	Q9Y2J8	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.13	-	pH 7.4, 23°C	Homo sapiens	H2O2

General Information

General Information	Comment	Organism
physiological function	phorbol 12-myristate 13-acetate-stimulated leukocytes citrullinate fibrinogen. The citrullination is markedly enhanced when ROS formation is inhibited by the NADPH oxidase inhibitor diphenyleneiodonium. Peptidylarginine deiminase released from stimulated leukocytes is unaffected by exogenously added H2O2 at concentrations up to 1000 microM	Homo sapiens

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Release 2023.1 (January 2023)