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Literature summary for 3.5.3.15 extracted from

  • Olson, J.S.; Lubner, J.M.; Meyer, D.J.; Grant, J.E.
    An in silico analysis of primary and secondary structure specificity determinants for human peptidylarginine deiminase types 2 and 4 (2017), Comput. Biol. Chem., 70, 107-115 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UM07 isoform Pad4
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Homo sapiens Q9Y2J8 isoform PAD2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PAD2 appears to favor citrullination of glycine-containing motifs. Distinct hydrophobic motifs are identified for PAD2 citrullination sites predicted to reside within alpha-helical and beta-sheet regions. There is potential substrate overlap between coil region citrullination and arginine methylation Homo sapiens ?
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additional information isoform PAD4 appears to favor citrullination of glycine-containing motifs. There is potential substrate overlap between coil region citrullination and arginine methylation Homo sapiens ?
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