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Literature summary for 3.5.3.15 extracted from

  • Jamali, H.; Khan, H.A.; Tjin, C.C.; Ellman, J.A.
    Cellular activity of new small molecule protein arginine deiminase 3 (PAD3) inhibitors (2016), ACS Med. Chem. Lett., 7, 847-851 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N-[([1,1'-biphenyl]-3-yl)methyl]-4-[(2-chloroethanimidoyl)amino]butanamide inhibitor at at 10 microM rescues thapsigargin-induced cell death in HEK293T cells Homo sapiens
N-[3-[5-([1,1'-biphenyl]-3-yl)-1H-imidazol-2-yl]propyl](chloro)ethanimidamide inhibitor at at 10 microM rescues thapsigargin-induced cell death in HEK293T cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9ULW8 isoform PAD3
-

Synonyms

Synonyms Comment Organism
PAD3
-
Homo sapiens
PADI3
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0054
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N-[3-[5-([1,1'-biphenyl]-3-yl)-1H-imidazol-2-yl]propyl](chloro)ethanimidamide
0.0058
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N-[([1,1'-biphenyl]-3-yl)methyl]-4-[(2-chloroethanimidoyl)amino]butanamide