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Literature summary for 3.5.3.15 extracted from

  • Lee, H.J.; Joo, M.; Abdolrasulnia, R.; Young, D.G.; Choi, I.; Ware, L.B.; Blackwell, T.S.; Christman, B.W.
    Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages (2010), J. Biol. Chem., 285, 39655-39662.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.15

Protein Variants

Protein Variants Comment Organism
DELTA1-385 IKKgamma co-immunoprecipitates truncation mutants, PAD2(1-385) and PAD2(355-672) Mus musculus
DELTA355-672 IKKgamma co-immunoprecipitates truncation mutants, PAD2(1-385) and PAD2(355-672) Mus musculus
Q358A substitution of Gln-358 (a putative ligand for Ca2+ binding) with an Ala abolishes co-immunoprecipitation with IKKgamma Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKKgamma and PAD2 can coimmunoprecipitate in the presence of the Ca2+ ionophore ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKgamma and PAD2 can coimmunoprecipitate in the presence of the Ca2+ ionophore Mus musculus ?
-
 ?
[IKKgamma]-L-arginine + H2O
-
 Mus musculus [IKKgamma]-L-citrulline + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PAD2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
55
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction overexpressing PAD2 reduces LPS-mediated COX-2 up-regulation by 50%. PAD2 overexpression also reduces NF-kappaB activity Mus musculus
physiological function incubation of purified PAD2 and IKKgamma proteins in the presence of Ca2+ citrullinate IKKgamma. Results demonstrate that PAD2 interacts with IKKgamma and suppresses NF-kappaB activity Mus musculus