Literature summary for 3.5.3.15 extracted from

Musse, A.A.; Li, Z.; Ackerley, C.A.; Bienzle, D.; Lei, H.; Poma, R.; Harauz, G.; Moscarello, M.A.; Mastronardi, F.G.
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system (2008), Dis. Model. Mech., 1, 229-240.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	overexpression of PAD2 increases expression of PAD4 but not other PAD enzymes	Homo sapiens
additional information	overexpression of PAD2 increases expression of PAD4 enzyme	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UM07	-	-
Homo sapiens	Q9Y2J8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
myelin basic protein L-arginine + H2O	-	Homo sapiens	myelin basic protein L-citrulline + NH3	-	?
myelin basic protein L-arginine + H2O	PAD2 overexpression in brain of transgenic mice leads to myelin loss in the central nervous system	Homo sapiens	myelin basic protein L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PAD2	isoform	Homo sapiens
PAD4	isoform	Homo sapiens
peptidylarginine deiminase	-	Homo sapiens

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Release 2023.1 (January 2023)