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Literature summary for 3.5.3.15 extracted from

  • Algeciras, M.E.; Bhattacharya, S.K.
    Targeting optic nerve citrullination in glaucoma: a role for protein-arginine deiminase 2 (PAD2) inhibitors (2007), Drugs Future, 32, 999-1005.
No PubMed abstract available
Search for more literature for 3.5.3.15

Application

Application Comment Organism
pharmacology PAD1 is a target in skin diseases including psoriasis Homo sapiens
pharmacology PAD2 is a target for treatment of glaucoma and multiple sclerosis Homo sapiens
pharmacology PAD3 is a target in skin diseases including psoriasis, PAD3-like protein is a target for treatment of certain cancers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-chloroacetamidine inhibits PAD4, inactivates covalent modification on Cys645 Homo sapiens
4-chloromercuribenzoate inhibits PAD3 Homo sapiens
BAPTA-AM inhibits PAD2; inhibits PAD2 Homo sapiens
benzoyl-N-dimethyl-Arg inhibits PAD4 Homo sapiens
benzoyl-N-methyl-Arg inhibits PAD4 Homo sapiens
Cl-amidine inhibits PAD4, inactivates covalent modification on Cys645 Homo sapiens
F-amidine inhibits PAD4, inactivates covalent modification on Cys645 Homo sapiens
interferon beta inhibits PAD2 Homo sapiens
iodoacetate inhibits PAD3 Homo sapiens
additional information methylated Arg derivatives are very poor or inactive inhibitors of PAD4 Homo sapiens
paclitaxel inhibits PAD2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PAD1 Homo sapiens 5829
-
cytosol PAD1 Rattus norvegicus 5829
-
cytosol PAD2 Homo sapiens 5829
-
cytosol PAD2 Rattus norvegicus 5829
-
cytosol PAD3 Homo sapiens 5829
-
cytosol PAD3 Rattus norvegicus 5829
-
cytosol PAD6 Rattus norvegicus 5829
-
cytosol PAD6 Homo sapiens 5829
-
nucleus PAD4 Homo sapiens 5634
-
nucleus PAD4 Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Homo sapiens
Ca2+ required for activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen-L-arginine + H2O Homo sapiens PAD4, involvement in rheumatoid arthritis fibrinogen-L-citrulline + NH3
-
 ir
filaggrin-L-arginine + H2O Homo sapiens PAD4, involvement in rheumatoid arthritis filaggrin-L-citrulline + NH3
-
 ir
glial fibrillary acidic protein-L-arginine + H2O Homo sapiens PAD2, involvement in Alzheimer's diease glial fibrillary acidic protein-L-citrulline + NH3
-
 ir
histone H2A-L-arginine + H2O Homo sapiens PAD4, involvement in rheumatoid arthritis histone H2A-L-citrulline + NH3
-
 ir
histone H3-L-arginine + H2O Homo sapiens PAD4, involvement in rheumatoid arthritis histone H3-L-citrulline + NH3
-
 ir
histone H4-L-arginine + H2O Homo sapiens PAD4, involvement in rheumatoid arthritis histone H4-L-citrulline + NH3
-
 ir
keratin-L-arginine + H2O Homo sapiens PAD2, involvement in psoriasis keratin-L-citrulline + NH3
-
 ir
additional information Homo sapiens the enzyme is involved in autoimmune rheumatoid arthritis ?
-
 ?
additional information Homo sapiens the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma ?
-
 ?
myelin basic protein-L-arginine + H2O Homo sapiens PAD2, involvement in multiple sclerosis myelin basic protein-L-citrulline + NH3
-
 ir
protein-L-arginine + H2O Rattus norvegicus
-
 protein-L-citrulline + NH3
-
 ir
protein-L-arginine + H2O Homo sapiens PAD1 protein-L-citrulline + NH3
-
 ir
trichohyalin-L-arginine + H2O Homo sapiens PAD3, involvement in skin disease trichohyalin-L-citrulline + NH3
-
 ir
vimentin-L-arginine + H2O Homo sapiens PAD2, involvement in Alzheimer's disease vimentin-L-citrulline + NH3
-
 ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme PAD4
-
Homo sapiens Q6TGC4 PAD6; isozyme PAD6
-
Homo sapiens Q9ULC6 PAD1; isozyme PAD1
-
Homo sapiens Q9ULW8 PAD3; isozyme PAD3
-
Homo sapiens Q9Y2J8 PAD2; isozyme PAD2
-
Rattus norvegicus
-
 isozyme PAD6
-
Rattus norvegicus O88806 PAD1; isozyme PAD1
-
Rattus norvegicus O88807 PAD4; isozyme PAD4
-
Rattus norvegicus P20717 PAD2; isozyme PAD2
-
Rattus norvegicus P70708 PAD3; isozyme PAD3
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cortical Homo sapiens
-
astrocyte cortical Rattus norvegicus
-
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
optic nerve glaucomatous Homo sapiens
-
optic nerve glaucomatous, increased expression of PAD2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen-L-arginine + H2O PAD4, involvement in rheumatoid arthritis Homo sapiens fibrinogen-L-citrulline + NH3
-
 ir
fibrinogen-L-arginine + H2O PAD4 Homo sapiens fibrinogen-L-citrulline + NH3
-
 ir
filaggrin-L-arginine + H2O PAD4, involvement in rheumatoid arthritis Homo sapiens filaggrin-L-citrulline + NH3
-
 ir
filaggrin-L-arginine + H2O PAD4 Homo sapiens filaggrin-L-citrulline + NH3
-
 ir
glial fibrillary acidic protein-L-arginine + H2O PAD2, involvement in Alzheimer's diease Homo sapiens glial fibrillary acidic protein-L-citrulline + NH3
-
 ir
glial fibrillary acidic protein-L-arginine + H2O PAD2 Homo sapiens glial fibrillary acidic protein-L-citrulline + NH3
-
 ir
histone H2A-L-arginine + H2O PAD4, involvement in rheumatoid arthritis Homo sapiens histone H2A-L-citrulline + NH3
-
 ir
histone H2A-L-arginine + H2O PAD4 Homo sapiens histone H2A-L-citrulline + NH3
-
 ir
histone H3-L-arginine + H2O PAD4, involvement in rheumatoid arthritis Homo sapiens histone H3-L-citrulline + NH3
-
 ir
histone H3-L-arginine + H2O PAD4 Homo sapiens histone H3-L-citrulline + NH3
-
 ir
histone H4-L-arginine + H2O PAD4, involvement in rheumatoid arthritis Homo sapiens histone H4-L-citrulline + NH3
-
 ir
histone H4-L-arginine + H2O PAD4 Homo sapiens histone H4-L-citrulline + NH3
-
 ir
keratin-L-arginine + H2O PAD2, involvement in psoriasis Homo sapiens keratin-L-citrulline + NH3
-
 ir
keratin-L-arginine + H2O PAD2 Homo sapiens keratin-L-citrulline + NH3
-
 ir
additional information the enzyme is involved in autoimmune rheumatoid arthritis Homo sapiens ?
-
 ?
additional information the enzyme is involved in autoimmune rheumatoid arthritis, isozyme PAD2 is also implicated in neurological diseases with or without ocular manifestations, e.g. multiple sclerosis, autoimmune encephalomyelitis, Alzheimer's disease, and glaucoma Homo sapiens ?
-
 ?
additional information no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6 Rattus norvegicus ?
-
 ?
additional information no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, e.g. PAD2 in glaucoma of the optic nerve, overview Homo sapiens ?
-
 ?
additional information no activity with free L-arginine, which is converted by EC 1.14.13.39, nitric oxide synthase, the enzyme is not identical with bacterial arginine deiminase, EC 3.5.3.6, PADs are involved in diverse diseases, overview Homo sapiens ?
-
 ?
myelin basic protein-L-arginine + H2O PAD2, involvement in multiple sclerosis Homo sapiens myelin basic protein-L-citrulline + NH3
-
 ir
myelin basic protein-L-arginine + H2O PAD2 Homo sapiens myelin basic protein-L-citrulline + NH3
-
 ir
protein-L-arginine + H2O
-
 Rattus norvegicus protein-L-citrulline + NH3
-
 ir
protein-L-arginine + H2O PAD1 Homo sapiens protein-L-citrulline + NH3
-
 ir
trichohyalin-L-arginine + H2O PAD3, involvement in skin disease Homo sapiens trichohyalin-L-citrulline + NH3
-
 ir
trichohyalin-L-arginine + H2O PAD3 Homo sapiens trichohyalin-L-citrulline + NH3
-
 ir
vimentin-L-arginine + H2O PAD2, involvement in Alzheimer's disease Homo sapiens vimentin-L-citrulline + NH3
-
 ir
vimentin-L-arginine + H2O PAD2 Homo sapiens vimentin-L-citrulline + NH3
-
 ir

Synonyms

Synonyms Comment Organism
PAD1
-
 Homo sapiens
PAD1
-
 Rattus norvegicus
PAD2
-
 Homo sapiens
PAD2
-
 Rattus norvegicus
PAD3
-
 Homo sapiens
PAD3
-
 Rattus norvegicus
PAD4
-
 Homo sapiens
PAD4
-
 Rattus norvegicus
PAD6
-
 Rattus norvegicus
PAD6
-
 Homo sapiens
peptidylarginine deiminase 2
-
 Homo sapiens
peptidylarginine deiminase 2
-
 Rattus norvegicus