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Literature summary for 3.5.3.15 extracted from

  • Pritzker, L.B.; Joshi, S.; Harauz, G.; Moscarello, M.A.
    Deimination of myelin basic protein 3.5.3.15. Effect of methylation of MBP on its deimination by peptidylarginine deiminase (2000), Biochemistry, 39, 5382-5388.
    View publication on PubMed
Search for more literature for 3.5.3.15

Organism

Organism UniProt Comment Textmining
Bos taurus
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Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification methylation of Arg106 is a naturally occuring modification of the enzyme that affects deimination of Arg residues Bos taurus
side-chain modification methylation of Arg107 is a naturally occuring modification of the enzyme that affects deimination of Arg residues Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myelin basic protein + H2O decreased methylation of myelin basic protein possibly by a shortage of S-adenosylmethionine or downregulation of the methyltransferase gen expression allows the peptidylarginine deiminase greater access to the arginyl groups of myelin basic protein Bos taurus ?
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