Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Leishmania mexicana |
Crystallization (Comment) | Organism |
---|---|
in complex with L-ornithine and inhibitors, hanging drop vapor diffusion method, using 10% (w/v) polyethylene glycol 10000, 5% (v/v) (+/-)-2-methyl-2,4-pentanediol, and 0.1 M HEPES, pH 7.3 | Leishmania mexicana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2(S)-amino-6-boronohexanoic acid | - |
Leishmania mexicana | |
nor-Nomega-hydroxy-L-arginine | - |
Leishmania mexicana | |
S-(2-boronoethyl)-L-cysteine | - |
Leishmania mexicana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
glycosome | - |
Leishmania mexicana | 20015 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | contains Mn2+ | Leishmania mexicana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | Leishmania mexicana | - |
L-ornithine + urea | - |
? | |
L-arginine + H2O | Leishmania mexicana MNYC/BZ/62/M379 | - |
L-ornithine + urea | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania mexicana | Q6TUJ5 | - |
- |
Leishmania mexicana MNYC/BZ/62/M379 | Q6TUJ5 | - |
- |
Purification (Comment) | Organism |
---|---|
cobalt-nitrilotriacetic acid column chromatography, and Q-HP anion-exchange column chromatography | Leishmania mexicana |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Leishmania mexicana | L-ornithine + urea | - |
? | |
L-arginine + H2O | - |
Leishmania mexicana MNYC/BZ/62/M379 | L-ornithine + urea | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | - |
Leishmania mexicana |
Synonyms | Comment | Organism |
---|---|---|
ARG | - |
Leishmania mexicana |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the first committed step in the biosynthesis of polyamines that enable cell growth and survival | Leishmania mexicana |