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Literature summary for 3.5.3.1 extracted from

  • Kenyon, N.J.; Bratt, J.M.; Linderholm, A.L.; Last, M.S.; Last, J.A.
    Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences (2008), Toxicol. Appl. Pharmacol., 230, 269-275.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information expression of arginase I strongly correlated with the presence of lung inflammation, as quantified by differential cell counts in lung lavage, suggesting that most, or all, of the arginase I in lungs of mice exposed to ovalbumin is present in the inflammatory cells rather than in the airway epithelium Mus musculus

Application

Application Comment Organism
medicine arginase gene expression in the lung is linked to asthma both in clinical studies of human patients and in the well-studied mouse model of ovalbumin-induced airway inflammation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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ovalbumin-sensitized Balb/c mice
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Source Tissue

Source Tissue Comment Organism Textmining
lung isolated microdissected airway preparations. Arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
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Mus musculus L-ornithine + urea
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?
additional information arginase II is constitutively expressed in the airways of normal mice, whereas arginase I is undetectable in normal airways, while its expression is increased in airways of mice exposed to ovalbumin Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
arginase I
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Mus musculus
arginase II
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Mus musculus