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Literature summary for 3.5.3.1 extracted from
- Determination of the catalytic pathway of a manganese arginase enzyme through density functional investigation (2009), Chemistry, 15, 8026-8036.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2(S)-amino-6-boronohexanoic acid | - |
Rattus norvegicus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | arginase is a better biological catalyst for arginine hydrolysis when both cations are retained and a hydroxide ion is present in the active site bridging the two Mn metal centers | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + H2O | - |
Rattus norvegicus | L-ornithine + urea | - |
? | |
| additional information | model cluster used to simulate the active site of arginase is built starting from the 1.7 A X-ray structure of rat liver arginase complexed with the inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arginase | - |
Rattus norvegicus |
| L-arginine amidinohydrolase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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