Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-2-amino-7-oxoheptanoic acid | - |
Homo sapiens | |
(S)-2-amino-7-oxoheptanoic acid | - |
Rattus norvegicus | |
additional information | arginase activity functionally inhibits nitric oxide synthase by depleting the substrate pool of L-arginine, and nitric oxide synthase activity potentially inhibits arginase by generating and releasing small amounts of the intermediate N-hydroxy-L-arginine, a competitive inhibitor of arginase, and also by generating nitric oxide itself, which can nitrosylate cysteine residues of human arginase I to modulate its activity; arginase activity functionally inhibits nitric oxide synthase by depleting the substrate pool of L-arginine, and nitric oxide synthase activity potentially inhibits arginase by generating and releasing small amounts of the intermediate N-hydroxy-L-arginine, a competitive inhibitor of arginase, and also by generating nitric oxide itself, which can nitrosylate cysteine residues of human arginase I to modulate its activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
L-arginine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | manganese metalloenzyme | Homo sapiens | |
Mn2+ | manganese metalloenzyme, Mn2+-Mn2+ cluster in the active site of each monomer | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05089 | - |
- |
Homo sapiens | P78540 | - |
- |
Rattus norvegicus | P07824 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
additional information | nonhepatic tissue | Homo sapiens | - |
vascular smooth muscle cell | - |
Homo sapiens | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Homo sapiens | L-ornithine + urea | - |
? | |
L-arginine + H2O | - |
Rattus norvegicus | L-ornithine + urea | - |
? | |
additional information | hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | - |
Homo sapiens |
trimer | trimeric quaternary structure in which each monomer adopts an alpha/betafold consisting of a central parallel eight-stranded beta-sheet flanked on both sides by several alpha-helices | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
arginase | - |
Homo sapiens |
arginase | - |
Rattus norvegicus |
arginase I | - |
Homo sapiens |
arginase I | - |
Rattus norvegicus |
arginase II | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
(S)-2-amino-7-oxoheptanoic acid | - |
Rattus norvegicus |