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Literature summary for 3.5.3.1 extracted from

  • Lam, T.L.; Wong, G.K.; Chong, H.C.; Cheng, P.N.; Choi, S.C.; Chow, T.L.; Kwok, S.Y.; Poon, R.T.; Wheatley, D.N.; Lo, W.H.; Leung, Y.C.
    Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest (2009), Cancer Lett., 277, 91-100.
    View publication on PubMed

Application

Application Comment Organism
drug development the application of rhArg-PEG alone or in combination with existing chemotherapeutic drugs may represent a specific and effective therapeutic strategy against human hepatocellular carcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
400
-
about, 30°C, pH 8.5 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
Homo sapiens L-ornithine + urea
-
?
additional information recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
arginase
-
Homo sapiens
recombinant human arginase I
-
Homo sapiens
rhArg-PEG
-
Homo sapiens