Literature summary for 3.5.3.1 extracted from

North, M.L.; Khanna, N.; Marsden, P.A.; Grasemann, H.; Scott, J.A.
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma (2009), Am. J. Physiol. Lung Cell Mol. Physiol., 296, L911-L920.

Search for more literature for 3.5.3.1

Protein Variants

Protein Variants	Comment	Organism
additional information	OVA/OVA mice, murine models of ovalbumin-induced airway inflammation	Mus musculus
additional information	OVA/OVA mice, murine models of ovalbumin-induced airway inflammation, ARG1 expression is similar to the sam ples from asthma patients. ARG1 is visibly increased throughout the lungs, and strong-positive staining is observed in infiltrating inflammatory cells, bronchiolar and alveolar macrophages, and the peribronchiolar regions in the OVA/OVA mice	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
S-(2-boronoethyl)-L-cysteine	BEC; BEC	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	control and physician-diagnosed asthma patients	-
Homo sapiens	P05089	control and physician-diagnosed asthma patients	-
Mus musculus	-	-	-
Mus musculus	Q61176	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Mus musculus	-
lung	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	lung ARG1 expression and activity is increased in human asthma. Expression of ARG1 is increased 4.4fold in lung tissue homogenates from asthma patients compared with controls	Homo sapiens
additional information	-	no significant differences in ARG2 protein expression is detected between asthma patients and controls by Western blotting or immunoprecipitation	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ARG1	-	Homo sapiens
ARG1	-	Mus musculus
ARG2	-	Mus musculus
ARG2	-	Homo sapiens
arginase 1	-	Mus musculus
arginase 1	-	Homo sapiens

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Release 2023.1 (January 2023)