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Literature summary for 3.5.3.1 extracted from

  • Iyamu, E.W.; Ekekezie, C.; Woods, G.M.
    In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes (2007), Br. J. Haematol., 139, 337-343.
    View publication on PubMed
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
Chloroquine inhibits arginase in a dose-dependent manner, and displays a linear competitive inhibition on sickle erythrocyte arginase Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.81
-
 L-arginine at pH 6.8 and 37°C Homo sapiens
2.08
-
 L-arginine at pH 6.8 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Homo sapiens
-
 L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte sickle erythrocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Homo sapiens L-ornithine + urea
-
 ?

Synonyms

Synonyms Comment Organism
L-arginine amidinohydrolase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.023
-
 Chloroquine at pH 6.8 and 37°C Homo sapiens
0.041
-
 Chloroquine at pH 7.4 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.077
-
 at pH 6.8 and 37°C Homo sapiens Chloroquine
0.109
-
 at pH 7.4 and 37°C Homo sapiens Chloroquine