Crystallization (Comment) | Organism |
---|---|
isoform arginase I in complex with inhibitor (S)-2-amino-7-oxoheptanoic acid. Inhibitor aldehyde moiety is hydrated to form the gem-diol, one hydroxyl group bridges the Mn2+ cluster and donates a hydrogen bond to D128, and the second hydroxyl group donates a hydrogen bond to E277 | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S,5E)-2-amino-7-oxohept-5-enoic acid | - |
Rattus norvegicus | |
(S)-2-amino-7-oxoheptanoic acid | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
recombinant enzyme | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
(S)-2-amino-7-oxoheptanoic acid | pH 9.5 | Rattus norvegicus | |
0.36 | - |
(2S,5E)-2-amino-7-oxohept-5-enoic acid | pH 9.5 | Rattus norvegicus |