Literature summary for 3.5.3.1 extracted from

Ming, X.F.; Barandier, C.; Viswambharan, H.; Kwak, B.R.; Mach, F.; Mazzolai, L.; Hayoz, D.; Ruffieux, J.; Rusconi, S.; Montani, J.P.; Yang, Z.
Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction (2004), Circulation, 110, 3708-3714.

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Activating Compound

Activating Compound	Comment	Organism	Structure
thrombin	up to 2fold stimulation, dose- and time-dependent	Homo sapiens

Application

Application	Comment	Organism
medicine	targeting vascular arginase as a therapeutic possibility for atherosclerosis. Thrombin enhances enzyme activity via small G-protein RhoA/ROCK in endothelial cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	endothelial cells isolated from umbilical veins	Homo sapiens	-

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Release 2023.1 (January 2023)