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Literature summary for 3.5.3.1 extracted from

  • Erdely, A.; Kepka-Lenhart, D.; Clark, M.; Zeidler-Erdely, P.; Poljakovic, M.; Calhoun, W.J.; Morris, S.M.
    Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages (2006), Am. J. Physiol. Lung Cell Mol. Physiol., 290, L534-L539.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
IL-4 interleukin IL-4, up to 16-fold stimulation of enzyme activity in RAW-264.7 cell, in combinantion with rolipram additional activation. No stimulation of enzyme in alveolar macrophages by IL-4 alone, but increase of stimulation by forskolin and 3-isobutyl-1-methylxanthine, IBMX, in presence of IL-4 Homo sapiens
additional information rolipram increases stimulation by interleukin IL-4 and transforming growth factor beta Homo sapiens
TGF-beta transforming growth factor, up to 5-fold stimulation, further stimulation in combination with rolipram Homo sapiens

Application

Application Comment Organism
medicine agents that elevate cAMP level significantly enhance induction of enzyme by cytokines. Consequences of increased enzyme expression should be evaluated when phosphodiesterase inhibitors are used for treatment of inflammatory disorders in which IL-4 and/or TGF-beta predominate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage alveolar macrophage Homo sapiens
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RAW-264.7 cell
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Homo sapiens
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