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Literature summary for 3.5.2.9 extracted from
- Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells (1998), Biochem. Pharmacol., 56, 743-749.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | clinical applications, substrate 5-oxo-L-proline sensitizes tumors to the alkylating agent melphalan | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA in pT7-7, subcloned into mammalian expression vector pRc/CMV, transfected into MCF7 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-2-Oxothiazolidine-4-carboxylate | competitive inhibitor | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + H2O + ATP | Homo sapiens | - |
L-glutamate + ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Homo sapiens | - |
breast cancer cell line MCF7 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | peripheral mononuclear cells | Homo sapiens | - |
| breast | normal and cancer tissues | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + H2O + ATP | - |
Homo sapiens | L-glutamate + ADP + phosphate | - |
? | |
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