Literature summary for 3.5.2.3 extracted from

Schroeder, P.E.; Patel, D.; Hasinoff, B.B.
The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites (2008), Drug Metab. Dispos., 36, 1780-1785.

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Application

Application	Comment	Organism
medicine	involved in metabolism of the cardioprotective druc dexrazoxane	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
5-aminoorotic acid	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-(2-amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]glycine + H2O	-	Rattus norvegicus	N,N'-[(1S)-1-methyl-1,2-ethanediyl]bis[N-(2-amino-2-oxoethyl)]glycine	-	ir
N-(2-amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]glycine + H2O	-	Rattus norvegicus	N,N'-[(1S)-1-methyl-1,2-ethanediyl]bis[N-(2-amino-2-oxoethyl)]glycine	-	ir

Synonyms

Synonyms	Comment	Organism
DHOase	-	Rattus norvegicus
dihydroorotase	-	Rattus norvegicus

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Release 2023.1 (January 2023)