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Literature summary for 3.5.2.17 extracted from
- Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein (2009), FEBS J., 276, 1999-2011.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
| expression in Escherichia coli strain BL21 | Homo sapiens |
| expression in Escherichia coli strain BL21 | Chilotilapia rhoadesii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | at pH 2-12 | Escherichia coli | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chilotilapia rhoadesii | - |
- |
- |
| Escherichia coli | P76341 | - |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Chilotilapia rhoadesii |
- |
Escherichia coli |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Escherichia coli |
| tetramer | structure variations depends on pH value | Homo sapiens |
| tetramer | structure variations depends on pH value | Chilotilapia rhoadesii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ecTRP | - |
Escherichia coli |
| hTTR | - |
Homo sapiens |
| sbTTR | - |
Chilotilapia rhoadesii |
| transthyretin | - |
Homo sapiens |
| transthyretin | - |
Chilotilapia rhoadesii |
| transthyretin-related protein | - |
Escherichia coli |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 66.7 | - |
melting temperature, below 66.7°C structure stable | Escherichia coli |
| 93 | - |
melting temperature, below 93.0°C structure stable | Chilotilapia rhoadesii |
| 97.8 | - |
melting temperature, below 97.8°C structure stable | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 3 | - |
below 3.0 separation into monomeric units | Escherichia coli |
| 4.6 | - |
below pH 4.6 separation into monomeric units | Chilotilapia rhoadesii |
| 5 | - |
below pH 5.0 separation into monomeric units | Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | estimated value between 5.5-6.0 | - |
additional information |
| Chilotilapia rhoadesii | estimated value between 5.5-6.0 | - |
additional information |
| Escherichia coli | estimated value | - |
8.2 |
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