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Literature summary for 3.5.1.99 extracted from

  • Strittmatter, F.; Gandaglia, G.; Benigni, F.; Bettiga, A.; Rigatti, P.; Montorsi, F.; Gratzke, C.; Stief, C.; Colciago, G.; Hedlund, P.
    Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats (2012), Eur. Urol., 61, 98-106.
    View publication on PubMed
Search for more literature for 3.5.1.99

Inhibitors

Inhibitors Comment Organism Structure
oleoyl ethylamide FAAH inhibitor Homo sapiens
oleoyl ethylamide FAAH inhibitor Mus musculus
oleoyl ethylamide FAAH inhibitor Rattus norvegicus
palmitoyl ethanolamide a non-CB1 non-CB2 cannabinoid-like compound Homo sapiens
palmitoyl ethanolamide a non-CB1 non-CB2 cannabinoid-like compound Mus musculus
palmitoyl ethanolamide a non-CB1 non-CB2 cannabinoid-like compound Rattus norvegicus
URB597 FAAH inhibitor Homo sapiens
URB597 FAAH inhibitor Mus musculus
URB597 FAAH inhibitor Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 x * 63000, about, SDS-PAGE Mus musculus
63000
-
 x * 63000, about, SDS-PAGE Homo sapiens
63000
-
 x * 63000, about, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Mus musculus i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
 ?
anandamide + H2O Homo sapiens i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
 ?
anandamide + H2O Rattus norvegicus i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
 ?
anandamide + H2O Rattus norvegicus Sprague-Dawley i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
 female
-
Rattus norvegicus Sprague-Dawley
-
 female
-

Source Tissue

Source Tissue Comment Organism Textmining
urinary bladder full-wall bladder and mucosa, urothelium, no FAAH immunoreactivity in other structures of the bladder Mus musculus
-
urinary bladder mucosa, urothelium, no FAAH immunoreactivity in other structures of the bladder Homo sapiens
-
urinary bladder mucosa, urothelium, no FAAH immunoreactivity in other structures of the bladder Rattus norvegicus
-
urothelium
-
 Homo sapiens
-
urothelium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O i.e. arachidonoyl ethanolamide Mus musculus arachidonic acid + ethanolamine
-
 ?
anandamide + H2O i.e. arachidonoyl ethanolamide Homo sapiens arachidonic acid + ethanolamine
-
 ?
anandamide + H2O i.e. arachidonoyl ethanolamide Rattus norvegicus arachidonic acid + ethanolamine
-
 ?
anandamide + H2O i.e. arachidonoyl ethanolamide Rattus norvegicus Sprague-Dawley arachidonic acid + ethanolamine
-
 ?

Subunits

Subunits Comment Organism
? x * 63000, about, SDS-PAGE Mus musculus
? x * 63000, about, SDS-PAGE Homo sapiens
? x * 63000, about, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
FAAH
-
 Mus musculus
FAAH
-
 Homo sapiens
FAAH
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction effects of FAAH inhibition on bladder function during urodynamics in awake rats, overview Rattus norvegicus
physiological function endocannabinoid-degrading enzyme fatty acid amide hydrolase. FAAH substrates in the urinary bladder act via local CB2-mediated signals Mus musculus
physiological function endocannabinoid-degrading enzyme fatty acid amide hydrolase. FAAH substrates in the urinary bladder act via local CB2-mediated signals Homo sapiens
physiological function endocannabinoid-degrading enzyme fatty acid amide hydrolase. FAAH substrates in the urinary bladder act via local CB2-mediated signals Rattus norvegicus