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Literature summary for 3.5.1.99 extracted from

  • Rakers, C.; Zoerner, A.A.; Engeli, S.; Batkai, S.; Jordan, J.; Tsikas, D.
    Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity (2012), Anal. Biochem., 421, 699-705.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
oleoyl oxazolopyridine i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM Canis lupus familiaris
oleoyl oxazolopyridine , i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics, overview Homo sapiens
additional information
-
additional information Michaelis-Menten kinetics, overview Canis lupus familiaris
0.0018
-
anandamide liver microsomes, pH 7.3, 37°C Canis lupus familiaris
0.0024
-
anandamide liver microsomes, pH 7.3, 37°C Homo sapiens
0.0033
-
anandamide liver mitochondria, pH 7.3, 37°C Homo sapiens
0.0123
-
anandamide recombinant enzyme, pH 7.3, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Canis lupus familiaris
-
-
mitochondrion
-
Homo sapiens 5739
-
additional information no activity in cytosol Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Homo sapiens i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
?
anandamide + H2O Canis lupus familiaris i.e. arachidonoyl ethanolamide arachidonic acid + ethanolamine
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O i.e. arachidonoyl ethanolamide Homo sapiens arachidonic acid + ethanolamine
-
?
anandamide + H2O i.e. arachidonoyl ethanolamide Canis lupus familiaris arachidonic acid + ethanolamine
-
?
anandamide + H2O i.e. arachidonoyl ethanolamide, LC-MS/MS analysis Homo sapiens arachidonic acid + ethanolamine
-
?
anandamide + H2O i.e. arachidonoyl ethanolamide, LC-MS/MS analysis Canis lupus familiaris arachidonic acid + ethanolamine
-
?
additional information the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton Homo sapiens ?
-
?
additional information the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton Canis lupus familiaris ?
-
?

Synonyms

Synonyms Comment Organism
FAAH
-
Homo sapiens
FAAH
-
Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Homo sapiens
7.3
-
assay at Canis lupus familiaris

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000243
-
recombinant enzyme, pH 7.3, 37°C Homo sapiens oleoyl oxazolopyridine