Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oleoyl oxazolopyridine | i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM | Canis lupus familiaris | |
oleoyl oxazolopyridine | , i.e. oloxa, a potent noncompetitive inhibitor, almost complete inhibition at 50 nM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Homo sapiens | |
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Canis lupus familiaris | |
0.0018 | - |
anandamide | liver microsomes, pH 7.3, 37°C | Canis lupus familiaris | |
0.0024 | - |
anandamide | liver microsomes, pH 7.3, 37°C | Homo sapiens | |
0.0033 | - |
anandamide | liver mitochondria, pH 7.3, 37°C | Homo sapiens | |
0.0123 | - |
anandamide | recombinant enzyme, pH 7.3, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Canis lupus familiaris | - |
- |
mitochondrion | - |
Homo sapiens | 5739 | - |
additional information | no activity in cytosol | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | Homo sapiens | i.e. arachidonoyl ethanolamide | arachidonic acid + ethanolamine | - |
? | |
anandamide + H2O | Canis lupus familiaris | i.e. arachidonoyl ethanolamide | arachidonic acid + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anandamide + H2O | i.e. arachidonoyl ethanolamide | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
anandamide + H2O | i.e. arachidonoyl ethanolamide | Canis lupus familiaris | arachidonic acid + ethanolamine | - |
? | |
anandamide + H2O | i.e. arachidonoyl ethanolamide, LC-MS/MS analysis | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
anandamide + H2O | i.e. arachidonoyl ethanolamide, LC-MS/MS analysis | Canis lupus familiaris | arachidonic acid + ethanolamine | - |
? | |
additional information | the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton | Homo sapiens | ? | - |
? | |
additional information | the substrate specificity of fatty acid ethanolamides decreased with decreasing length, number of double bonds, and lipophilicity of the fatty acid skeleton | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAAH | - |
Homo sapiens |
FAAH | - |
Canis lupus familiaris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Homo sapiens |
7.3 | - |
assay at | Canis lupus familiaris |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000243 | - |
recombinant enzyme, pH 7.3, 37°C | Homo sapiens | oleoyl oxazolopyridine |