Application | Comment | Organism |
---|---|---|
medicine | FAAH is a promising target for the treatment of several central and peripheral nervous system disorders, such as anxiety, pain and hypertension | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K142A | the greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241 | Rattus norvegicus |
K142A/S217A | the greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241 | Rattus norvegicus |
S217A | the greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | hybrid quantum mechanics/molecular mechanics (QM/MM) calculations reveal a new mechanism of nucleophile activation involving a LysSerSer catalytic triad. The proposed mechanism, shows that Lys142 and cis-Ser217 have a direct role in the activation of Ser241, in agreement with kinetic labelling experiments employing the highly reactive fluorophosphonatetetramethyl rhodamine. The greater reduction of Ser241 labelling rate in the K142A/S217A double mutant, compared to the K142A and S217A single mutants, suggests that Lys142 and Ser217 cooperate to deprotonate Ser241 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAAH | - |
Rattus norvegicus |