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Literature summary for 3.5.1.99 extracted from

  • Boger, D.L.; Fecik, R.A.; Patterson, J.E.; Miyauchi, H.; Patricelli, M.P.; Cravatt, B.F.
    Fatty acid amide hydrolase substrate specificity (2000), Bioorg. Med. Chem. Lett., 10, 2613-2616.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
anandamide + H2O Rattus norvegicus the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers ethanolamine + arachidonic acid
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?
oleamide + H2O Rattus norvegicus the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers oleic acid + NH3
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(11Z)-eicosenamide + H2O 105% of the activity with oleamide Rattus norvegicus (11Z)-eicosenoic acid + NH3
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?
(12Z)-octadecenamide + H2O 92% of the activity with oleamide Rattus norvegicus (12Z)-octadecenoic acid + NH3
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?
(13Z)-eicosenamide + H2O 103% of the activity with oleamide Rattus norvegicus (13Z)-eicosenoic acid + NH3
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?
(13Z)-octadecenamide + H2O 82% of the activity with oleamide Rattus norvegicus (13Z)-octadecenoic acid + NH3
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?
(15Z)-octadecenamide + H2O 90% of the activity with oleamide Rattus norvegicus (15Z)-octadecenoic acid + NH3
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?
(5Z)-eicosenamide + H2O 116% of the activity with oleamide Rattus norvegicus (5Z)-eicosenoic acid + NH3
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?
(6Z)-octadecenamide + H2O 91% of the activity with oleamide Rattus norvegicus (6Z)-octadecenoic acid + NH3
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?
(7Z)-octadecenamide + H2O 109% of the activity with oleamide Rattus norvegicus (7Z)-octadecenoic acid + NH3
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?
(8Z)-eicosenamide + H2O 112% of the activity with oleamide Rattus norvegicus (8Z)-eicosenoic acid + NH3
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?
(9E)-octadecenamide + H2O 52% of the activity with oleamide Rattus norvegicus (9E)-octadecenoic acid + NH3
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?
(9Z)-tetradec-9-enamide + H2O 86% of the activity with oleamide Rattus norvegicus myristoleic acid + NH3
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?
(9Z,12Z)-octadeca-9,12-dienamide + H2O 104% of the activity with oleamide Rattus norvegicus (9Z,12Z)-octadeca-9,12-dienoate + NH3
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?
11,14,17-eicosatrienamide + H2O 140% of the activity with oleamide Rattus norvegicus 11,14,17-eicosatrienoic acid + NH3
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?
11,14-eicosadienamide + H2O 127% of the activity with oleamide Rattus norvegicus ? + NH3
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?
2,2-dimethyloleamide + H2O 3% of the activity with oleamide Rattus norvegicus 2,2-dimethyloleic acid + NH3
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?
2-methyloleamide + H2O 7% of the activity with oleamide Rattus norvegicus 2-methyloleic acid + NH3
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?
8,11,14-eicosatrienamide + H2O 138% of the activity with oleamide Rattus norvegicus 8,11,14-eicosatrienoic acid + NH3
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?
alpha-linolenamide + H2O 138% of the activity with oleamide Rattus norvegicus ? + NH3
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?
anandamide + H2O the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers Rattus norvegicus ethanolamine + arachidonic acid
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?
anandamide + H2O 168% of the activity with oleamide Rattus norvegicus ethanolamine + arachidonic acid
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?
arachidonamide + H2O 311% of the activity with oleamide Rattus norvegicus arachidonic acid + NH3
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?
dodecanoamide + H2O 74% of the activity with oleamide Rattus norvegicus dodecanoic acid + NH3
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?
erucamide + H2O 83% of the activity with oleamide Rattus norvegicus ? + NH3
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?
linoelaidamide + H2O 54% of the activity with oleamide Rattus norvegicus (9E,12E)-octadeca-9,12-dienoic acid + NH3
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?
additional information FAAH is an enzyme of broad substrate specificity and is capable of hydrolyzing a wide array of unsaturated, and to a lesser extent saturated, fatty acid primary amides. However, when substituted adjacent to the amide carbonyl, the substrates can be made sterically or electronically resistant to hydrolysis. Long chain saturated fatty acid amides are hydrolyzed slower than the corresponding Z unsaturated fatty acid amides and the rate of hydrolysis increases incrementally with increases in the degree of unsaturation Rattus norvegicus ?
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?
myristic amide + H2O 83% of the activity with oleamide Rattus norvegicus myristic acid + NH3
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?
nervonamide + H2O 82% of the activity with oleamide Rattus norvegicus ? + NH3
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?
oleamide + H2O
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Rattus norvegicus oleic acid + NH3
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?
oleamide + H2O the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers Rattus norvegicus oleic acid + NH3
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?
palmitoamide + H2O 72% of the activity with oleamide Rattus norvegicus palmitic acid + NH3
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?
palmitoleamide + H2O 79% of the activity with oleamide Rattus norvegicus palmitoleic acid + NH3
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?
stearamide + H2O 69% of the activity with oleamide Rattus norvegicus stearic acid + NH3
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?

Synonyms

Synonyms Comment Organism
anandamide amidohydrolase
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Rattus norvegicus
FAAH
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Rattus norvegicus
oleamide hydrolase
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Rattus norvegicus