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Literature summary for 3.5.1.99 extracted from
- Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide (2001), Biochem. Pharmacol., 62, 517-26.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
- |
Sus scrofa |
| FAAH is cloned from rat liver plasma membranes and expressed in COS-7 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ibuprofen | - |
Rattus norvegicus |  |
| additional information | fatty acid-derived FAAH inhibitors | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound to | Mus musculus | 16020 | - |
| membrane | bound to | Homo sapiens | 16020 | - |
| membrane | bound to | Rattus norvegicus | 16020 | - |
| membrane | bound to | Sus scrofa | 16020 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Sus scrofa | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| basophilic leukemia cell | - |
Rattus norvegicus | - |
| blood platelet | very little expression | Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| C6 glioma cell | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lymphocyte | - |
Homo sapiens | - |
| macrophage | - |
Rattus norvegicus | - |
| additional information | not in human HeLa epithelioid carcinoma. Human HMC-1 mast cells show FAAH activity only when 5-lipoxygenase activity is inhibited | Homo sapiens | - |
| N18TG2 cell | - |
Mus musculus | - |
| neuroblastoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| anandamide + H2O | - |
Mus musculus | ethanolamine + arachidonic acid | - |
? | |
| anandamide + H2O | - |
Homo sapiens | ethanolamine + arachidonic acid | - |
? | |
| anandamide + H2O | - |
Rattus norvegicus | ethanolamine + arachidonic acid | - |
? | |
| anandamide + H2O | - |
Sus scrofa | ethanolamine + arachidonic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAAH | - |
Mus musculus |
| FAAH | - |
Homo sapiens |
| FAAH | - |
Rattus norvegicus |
| FAAH | - |
Sus scrofa |
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Release 2023.1 (January 2023)
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