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Literature summary for 3.5.1.99 extracted from

  • Vandevoorde, S.; Fowler, C.J.
    Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate (2005), Br. J. Pharmacol., 145, 885-893.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one
-
Rattus norvegicus
3'-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate
-
Rattus norvegicus
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide i.e. VDM11, inhibits the metabolism of anandamide by rat brain FAAH. Inhibition may at least in part be a consequence of the compound acting as an alternative substrate Rattus norvegicus
N-(4-hydroxyphenyl)arachidonylamide i.e. AM404, inhibits the metabolism of anandamide by rat brain FAAH Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague–Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague–Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O
-
Rattus norvegicus ethanolamine + arachidonic acid
-
?
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide + H2O the rate of metabolism of VDM11 is about 15–20% of that for anandamide Rattus norvegicus 4-amino-m-cresol + NH3
-
?

Synonyms

Synonyms Comment Organism
FAAH
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0021
-
N-(4-hydroxyphenyl)arachidonylamide in the presence of fatty acid-free bovine serum albumin (0.125% w/v). In the absence of fatty acid-free bovine serum albumin, the IC50 value is reduced Rattus norvegicus
0.0026
-
N-(4-hydroxy-2-methylphenyl) arachidonoyl amide in the presence of fatty acid-free bovine serum albumin (0.125% w/v). In the absence of fatty acid-free bovine serum albumin, the IC50 value is reduced Rattus norvegicus