Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of homozygous Hdac2-/- and heterozygous Hdac1-/+/Hdac2-/- isozyne HDAC2 knockout mutant oocytes, penotypes overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-Lys16-histone H4 + H2O | Mus musculus | - |
acetate + histone H4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P70288 | isozyme HDAC2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-Lys16-histone H4 + H2O | - |
Mus musculus | acetate + histone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC2 | - |
Mus musculus |
histone deacetylase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | depleting maternal isozyme HDAC2 results in hyperacetylation of H4K16, while normal deacetylation of other lysine residues of histone H3 or H4 is observed, and defective chromosome condensation and segregation during oocyte maturation occurs in a subpopulation of oocytes, leading to increased incidence of aneuploidy likely accounts for the observed sub-fertility of mice harboring Hdac2-defective oocytes. The infertility of mice harboring Hdac1-/+/Hdac2-/- oocytes is attributed to failure of those few eggs that properly mature to metaphase II to initiate DNA replication following fertilization. Hdac1-/+/Hdac2-/- eggs are fertilized but fail to initiate DNA replication. The increased amount of acetylated H4K16 likely impairs kinetochore function in oocytes lacking isozyme HDAC2 because kinetochores in mutant oocytes are less able to form coldstable microtubule attachments and less CENP-A is located at the centromere. Phenotype, overview | Mus musculus |
physiological function | histone deacetylase 2 regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. HDAC2 is the major isozyme that regulates global histone acetylation during oocyte development and is largely responsible for the deacetylation of H4K16 during maturation. Histone deacetylation that occurs during oocyte maturation is critical for proper chromosome segregation | Mus musculus |