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Literature summary for 3.5.1.98 extracted from

  • Meyners, C.; Baud, M.G.; Fuchter, M.J.; Meyer-Almes, F.J.
    Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors (2014), Anal. Biochem., 460, 39-46.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of His-tagged enzyme Alcaligenes sp.
recombinant expression of His-tagged isozyme HDAC8 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid hydroxyamide phenylamide
-
Alcaligenes sp.
2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid hydroxyamide phenylamide
-
Homo sapiens
additional information enzyme binding mechanisms, overview Alcaligenes sp.
additional information enzyme binding mechanisms, overview; enzyme binding mechanisms, overview; enzyme binding mechanisms, overview Homo sapiens
N-hydroxy-4-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}butanamide
-
Alcaligenes sp.
N-hydroxy-4-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}butanamide
-
Homo sapiens
N-hydroxy-5-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}pentanamide
-
Alcaligenes sp.
N-hydroxy-5-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}pentanamide
-
Homo sapiens
N-hydroxy-6-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}hexanamide
-
Alcaligenes sp.
N-hydroxy-6-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}hexanamide
-
Homo sapiens
N-hydroxy-7-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}heptanamide
-
Alcaligenes sp.
N-hydroxy-7-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}heptanamide
-
Homo sapiens
N-hydroxy-8-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}octanamide
-
Alcaligenes sp.
N-hydroxy-8-{[5-(propan-2-yl)naphthalene-1-sulfonyl]amino}octanamide
-
Homo sapiens
N-hydroxy-N~3~-[5-(propan-2-yl)naphthalene-1-sulfonyl]-beta-alaninamide
-
Alcaligenes sp.
N-hydroxy-N~3~-[5-(propan-2-yl)naphthalene-1-sulfonyl]-beta-alaninamide
-
Homo sapiens
suberoylanilide hydroxamic acid
-
Alcaligenes sp.
suberoylanilide hydroxamic acid complete inhibition; complete inhibition Homo sapiens
suberoylanilide trifluoromethylketone
-
Alcaligenes sp.
suberoylanilide trifluoromethylketone
-
Homo sapiens
trichostatin A
-
Alcaligenes sp.
trichostatin A
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information enzyme kinetic calculations, overview Alcaligenes sp.
additional information
-
additional information enzyme kinetic calculations, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Alcaligenes sp. Q70I53 i.e. Bordetella sp. strain FB188
-
Alcaligenes sp. DSM 11172 Q70I53 i.e. Bordetella sp. strain FB188
-
Homo sapiens Q13547 isozyme HDAC1
-
Homo sapiens Q9BY41 isozyme HDAC8
-
Homo sapiens Q9UBN7 isozyme HDAC6
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-acetyl-Lys-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Boc-acetyl-Lys + 7-amino-4-methylcoumarin
-
?
Boc-trifluoroacetyl-Lys-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Boc-trifluoroacetyl-Lys + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
deacetylase-like amidohydrolase
-
Alcaligenes sp.
FB188 HDAH
-
Alcaligenes sp.
HDAC1
-
Homo sapiens
HDAC6
-
Homo sapiens
HDAC8
-
Homo sapiens
HDAH
-
Alcaligenes sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Alcaligenes sp.
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Alcaligenes sp.
8
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetic calculations, Kd values, detailed overview Alcaligenes sp.
additional information
-
additional information inhibition kinetic calculations, Kd values, detailed overview Homo sapiens