Crystallization (Comment) | Organism |
---|---|
modeling studies using inhibitor 6-[(9H-fluoren-3-ylmethyl)(3-phenoxybenzyl)amino]-N-hydroxyhexanamide and histone deacetylase-like protein, PDB ID: 1C3R. Inhibitor fills the equivalent space at the protein surface and occupies the catalytic binding site, coordinating the fundamental zinc ion | Aquifex aeolicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-[(9H-fluoren-3-ylmethyl)(3-phenoxybenzyl)amino]-N-hydroxyhexanamide | simultaneous and efficient interactions of compound with both the enzyme surface and the tubular binding pocket, through proper selection of its arm groups, are critical for potential antagonist activity | Aquifex aeolicus | |
6-[(9H-fluoren-3-ylmethyl)(3-phenoxybenzyl)amino]-N-hydroxyhexanamide | - |
Homo sapiens | |
6-[(biphenyl-4-ylmethyl)[4-[(4-bromobenzyl)oxy]benzyl]amino]-N-hydroxyhexanamide | - |
Homo sapiens | |
6-[[4-[(4-bromobenzyl)oxy]benzyl](9H-fluoren-3-ylmethyl)amino]-N-hydroxyhexanamide | - |
Homo sapiens | |
trichostatin A | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aquifex aeolicus | O67135 | - |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fluor de Lys + H2O | - |
Homo sapiens | ? | - |
? | |
Fluor de Lys + H2O | - |
Aquifex aeolicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDLP | - |
Aquifex aeolicus |
histone deacetylase-like protein | - |
Aquifex aeolicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000022 | - |
HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 | Homo sapiens | trichostatin A | |
0.00007 | - |
HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 | Homo sapiens | 6-[(9H-fluoren-3-ylmethyl)(3-phenoxybenzyl)amino]-N-hydroxyhexanamide | |
0.00017 | - |
HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 | Homo sapiens | 6-[(biphenyl-4-ylmethyl)[4-[(4-bromobenzyl)oxy]benzyl]amino]-N-hydroxyhexanamide | |
0.00018 | - |
HDAC activity in HeLa nuclear cell extracts, 25°C, pH 8.0 | Homo sapiens | 6-[[4-[(4-bromobenzyl)oxy]benzyl](9H-fluoren-3-ylmethyl)amino]-N-hydroxyhexanamide |