Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-(cyclohexylcarbamothioyl)benzamide | 10 microM, 5.6fold activation of HDAC8. No activation of other HDAC isoenzymes | Homo sapiens | |
N-(phenylcarbamothioyl)benzamide | 10 microM, 12fold activation of HDAC8. No activation of other HDAC isoenzymes | Homo sapiens | |
N-[(3,5-dimethoxyphenyl)carbamothioyl]benzamide | 10 microM, 8.4fold activation of HDAC8. No activation of other HDAC isoenzymes | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.23 | - |
Fluor de Lys HDAC8 substrate | presence of activator N-(phenylcarbamothioyl)benzamide, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.744 | - |
Fluor de Lys HDAC8 substrate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fluor de Lys HDAC8 substrate + H2O | - |
Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
Fluor de Lys HDAC8 substrate | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.036 | - |
Fluor de Lys HDAC8 substrate | presence of activator N-(phenylcarbamothioyl)benzamide, pH not specified in the publication, temperature not specified in the publication | Homo sapiens |