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Literature summary for 3.5.1.98 extracted from

  • Singh, R.K.; Mandal, T.; Balsubramanian, N.; Viaene, T.; Leedahl, T.; Sule, N.; Cook, G.; Srivastava, D.K.
    Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate (2011), Bioorg. Med. Chem. Lett., 21, 5920-5923.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
N-(cyclohexylcarbamothioyl)benzamide 10 microM, 5.6fold activation of HDAC8. No activation of other HDAC isoenzymes Homo sapiens
N-(phenylcarbamothioyl)benzamide 10 microM, 12fold activation of HDAC8. No activation of other HDAC isoenzymes Homo sapiens
N-[(3,5-dimethoxyphenyl)carbamothioyl]benzamide 10 microM, 8.4fold activation of HDAC8. No activation of other HDAC isoenzymes Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.23
-
Fluor de Lys HDAC8 substrate presence of activator N-(phenylcarbamothioyl)benzamide, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.744
-
Fluor de Lys HDAC8 substrate pH not specified in the publication, temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fluor de Lys HDAC8 substrate + H2O
-
Homo sapiens ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.007
-
Fluor de Lys HDAC8 substrate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.036
-
Fluor de Lys HDAC8 substrate presence of activator N-(phenylcarbamothioyl)benzamide, pH not specified in the publication, temperature not specified in the publication Homo sapiens