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Literature summary for 3.5.1.98 extracted from

  • Kim, I.A.; No, M.; Lee, J.M.; Shin, J.H.; Oh, J.S.; Choi, E.J.; Kim, I.H.; Atadja, P.; Bernhard, E.J.
    Epigenetic modulation of radiation response in human cancer cells with activated EGFR or HER-2 signaling: potential role of histone deacetylase 6 (2009), Radiother. Oncol., 92, 125-132.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
LBH589 pan-histone deacetylase inhibitor Homo sapiens
SK7041 i.e. 4-dimethylamino-N-[4-(2-hydroxylcarbamoyl-vinyl)benzyl] benzamide Homo sapiens
trichostatin A
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-lysine-alpha-tubulin + H2O Homo sapiens
-
acetate + alpha-tubulin
-
?
N-acetyl-lysine-heat shock protein 90 + H2O Homo sapiens
-
acetate + heat shock protein 90
-
?
N-acetyl-lysine-histone H3 + H2O Homo sapiens
-
acetate + histone H3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-
SK-BR-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-alpha-tubulin + H2O
-
Homo sapiens acetate + alpha-tubulin
-
?
N-acetyl-lysine-heat shock protein 90 + H2O
-
Homo sapiens acetate + heat shock protein 90
-
?
N-acetyl-lysine-histone H3 + H2O
-
Homo sapiens acetate + histone H3
-
?

Synonyms

Synonyms Comment Organism
HDAC6
-
Homo sapiens
histone deacetylase 6
-
Homo sapiens

General Information

General Information Comment Organism
physiological function ectopic overexpression of HDAC6 isotype increases the levels of phosphorylated epidermal growth factor receptor and phosphorylated AKT expression. HDAC6 plays an important role in the modulation of radiation response of epidermal growth factor receptor and human epidermal growth factor receptor 2-activated cells Homo sapiens