Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LBH589 | pan-histone deacetylase inhibitor | Homo sapiens | |
SK7041 | i.e. 4-dimethylamino-N-[4-(2-hydroxylcarbamoyl-vinyl)benzyl] benzamide | Homo sapiens | |
trichostatin A | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-alpha-tubulin + H2O | Homo sapiens | - |
acetate + alpha-tubulin | - |
? | |
N-acetyl-lysine-heat shock protein 90 + H2O | Homo sapiens | - |
acetate + heat shock protein 90 | - |
? | |
N-acetyl-lysine-histone H3 + H2O | Homo sapiens | - |
acetate + histone H3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-alpha-tubulin + H2O | - |
Homo sapiens | acetate + alpha-tubulin | - |
? | |
N-acetyl-lysine-heat shock protein 90 + H2O | - |
Homo sapiens | acetate + heat shock protein 90 | - |
? | |
N-acetyl-lysine-histone H3 + H2O | - |
Homo sapiens | acetate + histone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC6 | - |
Homo sapiens |
histone deacetylase 6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ectopic overexpression of HDAC6 isotype increases the levels of phosphorylated epidermal growth factor receptor and phosphorylated AKT expression. HDAC6 plays an important role in the modulation of radiation response of epidermal growth factor receptor and human epidermal growth factor receptor 2-activated cells | Homo sapiens |