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Literature summary for 3.5.1.98 extracted from

  • Leone, V.; Mansueto, G.; Pierantoni, G.M.; Tornincasa, M.; Merolla, F.; Cerrato, A.; Santoro, M.; Grieco, M.; Scaloni, A.; Celetti, A.; Fusco, A.
    CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (2010), Oncogene, 29, 4341-4351.
    View publication on PubMed
Search for more literature for 3.5.1.98

Inhibitors

Inhibitors Comment Organism Structure
trichostatin A
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-CPAP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-histone H3 + H2O
-
 Homo sapiens acetate + histone H3
-
 ?

Synonyms

Synonyms Comment Organism
HDAC1
-
 Homo sapiens
histone deacetylase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function HDAC catalyze the removal of acetyl groups from core histones inducing local condensation of chromatin. Therefore, HDACs are generally considered repressors of transcription. Coiled-coil domain-containing protein 6 physically interacts with HDAC1 on the amphiregulin promoter. Coiled-coil domain-containing protein 6 requires HDAC1 activity to repress cAMP responsive element binding protein 1 target gene transcription Homo sapiens