Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293-EBNA cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-tubulin + H2O | major HDAC6 substrate | Homo sapiens | tubulin + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC6 | - |
Homo sapiens |
histone deacetylase 6 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6 mRNA and protein expression and reduces HDAC6 enzyme activity in non-neuronal as well as in neuronal cells | down |
General Information | Comment | Organism |
---|---|---|
physiological function | HDAC6 is necessary for protein aggregate formation and degradation | Homo sapiens |