Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
114000 | - |
truncated isoform of the HDAC6p114 protein, SDS-PAGE | Homo sapiens |
131000 | - |
HDAC6p131, major isoform of histone deacetlyase 6, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-tubulin + H2O | Homo sapiens | splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-tubulin + H2O | splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC6 | - |
Homo sapiens |
HDAC6p114 | splicing variant of histone deacetylase 6 lacking the first 152 amino acids from N-terminus in the major isoform HDAC6p131 protein | Homo sapiens |
HDAC6p131 | major isoform of histone deacetylase 6 | Homo sapiens |
histone deacetylase 6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HDAC6 mediates TGF-beta1-induced epithelial-mesenchymal transition in A-549 cells. Splicing variant HDAC6p114 is required for TGF-beta1-activated gene expression associated with epithelial-mesenchymal transition in A-549 cells | Homo sapiens |