Application | Comment | Organism |
---|---|---|
medicine | inhibitors of histone deacetylase activity sensitize colon cancer cells to interferon gamma-induced apoptosis through cooperative negative regulation of the Bcl-x expression | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of isoforms HDAC1, HDAC2, HDAC3 by RNAi markedly decreases interferon gamma-driven gene activation. Overexpression of the enzymes enhances STAT1-driven transcriptional activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Butyrate | inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation | Homo sapiens | |
suberoylanilide hydroxamic acid | inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation | Homo sapiens | |
trichostatin A | inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
HKE-3 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |