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Literature summary for 3.5.1.98 extracted from

  • Guardiola, A.R.; Yao, T.P.
    Molecular cloning and characterization of a novel histone deacetylase HDAC10 (2002), J. Biol. Chem., 277, 3350-3356.
    View publication on PubMed
Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment) Organism
expression in U2OS and 293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H135A loss of catalytic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information isoform HDAC10 is resistant to inhibitors trapoxin B and sodium butyrate Homo sapiens
trichostatin A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 x * 70000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q969S8 isoform HDAC10, enzyme is most similar to isoform HDAC6
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information sequence contains a potential N-glycosylation site at D616, 3 putative protein kinase C phosphorylation sites, and several putative casein kinase phosphorylation sites Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform HDAC10 represses transcription independent of its deacetylase activity Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens